Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631
文献类型: 外文期刊
第一作者: Sironi, Laura
作者: Sironi, Laura;Williams, John L.;Ramelli, Paola;Stella, Alessandra;Mariani, Paola;Moreno-Martin, Ana M.;Lombardi, Guerino;Cordioli, Paolo;Han Jianlin;Weigend, Steffen
作者机构:
关键词: avian influenza;highly pathogenic H7N1;chicken experimental infection;Mx gene;resistance
期刊名称:VIROLOGY ( 影响因子:3.616; 五年影响因子:3.967 )
ISSN: 0042-6822
年卷期: 2008 年 380 卷 1 期
页码:
收录情况: SCI
摘要: Five chicken lines were experimentally infected with a HPAI H7N1 virus, to examine the variation in susceptibility to infection. Three lines showed high susceptibility to the virus, while two showed some resistance, with 7 out of 20, and 11 out of 15 birds, respectively, remaining healthy and surviving the experimental infection. Genotyping for the G/A polymorphism at position 2032 of Mx cDNA showed that one line was fixed for the C allele, and two were segregating for A and G alleles. Birds in the other two lines were selected to be fixed for the A allele. Statistical analyses indicated that the Mx genotype did not affect the clinical Status OF the time Course of infection after viral inoculation. (C) 2008 Elsevier Inc. All rights reserved.
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