Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631

文献类型： 外文期刊

第一作者： Sironi, Laura

作者： Sironi, Laura;Williams, John L.;Ramelli, Paola;Stella, Alessandra;Mariani, Paola;Moreno-Martin, Ana M.;Lombardi, Guerino;Cordioli, Paolo;Han Jianlin;Weigend, Steffen

作者机构：

关键词： avian influenza;highly pathogenic H7N1;chicken experimental infection;Mx gene;resistance

期刊名称：VIROLOGY （ 影响因子：3.616； 五年影响因子：3.967 ）

ISSN： 0042-6822

年卷期： 2008 年 380 卷 1 期

页码：

收录情况： SCI

摘要： Five chicken lines were experimentally infected with a HPAI H7N1 virus, to examine the variation in susceptibility to infection. Three lines showed high susceptibility to the virus, while two showed some resistance, with 7 out of 20, and 11 out of 15 birds, respectively, remaining healthy and surviving the experimental infection. Genotyping for the G/A polymorphism at position 2032 of Mx cDNA showed that one line was fixed for the C allele, and two were segregating for A and G alleles. Birds in the other two lines were selected to be fixed for the A allele. Statistical analyses indicated that the Mx genotype did not affect the clinical Status OF the time Course of infection after viral inoculation. (C) 2008 Elsevier Inc. All rights reserved.

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