Antidiabetic activity of Mung bean extracts in diabetic KK-A(y) mice

文献类型： 外文期刊

第一作者： Yao, Yang

作者： Yao, Yang;Ren, Guixing;Chen, Feng;Wang, Mingfu;Wang, Jiashi

作者机构：

关键词： mung bean sprouts;mung bean seed coats;antidiabetic activity;KK-A(y) mice

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2008 年 56 卷 19 期

页码：

收录情况： SCI

摘要： The antidiabetic effects of Mung bean sprout (MBS) extracts and Mung bean seed coat (MBSC) extracts were investigated in type 2 diabetic mice. Male KK-A(y) mice and C57BL/6 mice were used in this study. In KK-Ay mice, the blood glucose, plasma C-peptide, glucagon, total cholesterol, triglyceride, and blood urea nitrogen (BUN) levels were significantly higher than those in the C57BL/6 mice (P < 0.001, P < 0.001, P < 0.01, P < 0.001, P < 0.01, and P < 0.01). In addition, KK-Ay mice showed an obvious decrease in insulin immunoreactivity in pancreas as well. MBS and MBSC were orally administrated to KK-Ay mice for 5 weeks. It was found that MBS (2 g/kg) and MBSC (3 g/kg) lowered blood glucose, plasma C-peptide, glucagon, total cholesterol, triglyceride, and BUN levels and at the same time markedly improved glucose tolerance and increased insulin immunoreactive levels. These results suggest that MBS and MBSC exert an antidiabetic effect in type 2 diabetic mice.

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