Effects on the bones of vanadyl acetylacetonate by oral administration: a comparison study in diabetic rats

文献类型： 外文期刊

第一作者： Zhang, Shuang-Qing

作者： Zhang, Shuang-Qing;Chen, Guo-Hua;Lu, Wan-Liang;Zhang, Qiang

作者机构：

关键词： vanadyl acetylacetonate;diabetes;bone markers;bone biomechanics;bone histomorphometry

期刊名称：JOURNAL OF BONE AND MINERAL METABOLISM （ 影响因子：2.626； 五年影响因子：2.612 ）

ISSN： 0914-8779

年卷期： 2007 年 25 卷 5 期

页码：

收录情况： SCI

摘要： Oral delivery, rather than parenteral administration, would be beneficial for treating diabetic mellitus owing to the need for a long-term regimen. The objectives of this study were to evaluate oral delivery tolerance and the effects on the bone of accumulated vanadium following the long-term administration of vanadyl acetylacetonate (VAC). Normal and diabetic rats were intragastrically administered VAC at a dose of 3mg vanadium/kg body weight once daily for 35 consecutive days. VAC did not cause any obvious signs of diarrhea, any changes in kidney or liver, or deaths in any group. The phosphate levels in the bone were slightly increased, and the calcium levels in the bone were not obviously changed as compared with those of the rat group not receiving VAC. After administration of VAC, the decreased ultimate strength, trabecular thickness, mineral apposition rate, and plasma osteocalcin in diabetic rats were either improved or normalized, but reduced bone mineral density (BMD) in diabetic rats was not improved. None of the parameters evaluated in normal rats were altered. The results indicate that the oral VAC is tolerated and benefits the diabetic osteopathy of rats, but seems not to influence the bone of normal rats. They also suggest that VAC improves diabetes-related bone disorders, primarily by improving the diabetic state.

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