Functional role of aspartic proteinase cathepsin D in insect metamorphosis

文献类型： 外文期刊

第一作者： Gui, Zhong Zheng

作者： Gui, Zhong Zheng;Lee, Kwang Sik;Kim, Bo Yeon;Choi, Yong Soo;Wei, Ya Dong;Choo, Young Moo;Kang, Pil Don;Yoon, Hyung Joo;Kim, Iksoo;Je, Yeon Ho;Seo, Sook Jae;Lee, Sang Mong;Guo, Xijie;Sohn, Hung Dae;Jin, Byung Rae

作者机构：

期刊名称：BMC DEVELOPMENTAL BIOLOGY （ 影响因子：1.978； 五年影响因子：2.533 ）

ISSN： 1471-213X

年卷期： 2006 年 6 卷

页码：

收录情况： SCI

摘要： Background: Metamorphosis is a complex, highly conserved and strictly regulated development process that involves the programmed cell death of obsolete larval organs. Here we show a novel functional role for the aspartic proteinase cathepsin D during insect metamorphosis. Results: Cathepsin D of the silkworm Bombyx mori (BmCatD) was ecdysone-induced, differentially and spatially expressed in the larval fat body of the final instar and in the larval gut of pupal stage, and its expression led to programmed cell death. Furthermore, BmCatD was highly induced in the fat body of baculovirus-infected B. mori larvae, suggesting that this gene is involved in the induction of metamorphosis of host insects infected with baculovirus. RNA interference (RNAi)-mediated BmCatD knock-down inhibited programmed cell death of the larval fat body, resulting in the arrest of larval-pupal transformation. BmCatD RNAi also inhibited the programmed cell death of larval gut during pupal stage. Conclusion: Based on these results, we concluded that BmCatD is critically involved in the programmed cell death of the larval fat body and larval gut in silkworm metamorphosis.

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