Field evaluation of a test for praziquantel resistance in Schistosoma sp.

文献类型： 外文期刊

第一作者： Kenworthy, JD

作者： Kenworthy, JD;Ye, P;Wu, GC;Yu, H;Shi, YJ;Li, H;Coles, GC

作者机构：

关键词： control methods;Trematoda;praziquantel;resistance detection;Schistosoma sp.

期刊名称：VETERINARY PARASITOLOGY （ 影响因子：2.738； 五年影响因子：2.951 ）

ISSN： 0304-4017

年卷期： 2003 年 113 卷 1 期

页码：

收录情况： SCI

摘要： A simple rapid test for detecting praziquantel resistance in Schistosoma sp., involving change in shape of miracidia on exposure to praziquantel, was evaluated in China. Tests on miracidia hatched from eggs collected from naturally infected goats were run in a field laboratory in Jiangxi Province and a research laboratory in Shanghai. The mean values in the two laboratories were not significantly different, but the variation between individual samples in the two laboratories suggests that a delineating dose will be required for routine diagnosis of resistance. Confirmation that resistance would have been detected in Schistosoma japonicum must await the isolation of a resistant isolate. The tests suggested that the infection in the goats was susceptible to praziquantel as did chemotherapy of water buffaloes with 25 mg/kg. This gave a 95% cure rate on the first treatment and 100% with a second treatment, similar to that found previously in human patients. (C) 2003 Elsevier Science B.V. All rights reserved.

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