The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism

文献类型： 外文期刊

第一作者： Liu, Yisong

作者： Liu, Yisong;Huang, Peng;Tang, Qi;Cheng, Pi;Zheng, Yajie;Zeng, Jianguo;Liu, Xiubin;Liu, Yisong;Huang, Peng;Qing, Zhixing;Tang, Qi;Cheng, Pi;Zheng, Yajie;Zeng, Jianguo;Liu, Xiubin;Huang, Peng;Tang, Qi;Cheng, Pi;Zheng, Yajie;Liu, Jinfeng;Zhuo, Yixiu;Yu, Linlan;Xiong, Xingyao;Zeng, Jianguo;Liu, Yisong;Huang, Jialu;Ma, Yongshuo;Zhou, Yuan;Zhang, Zhonghua;Shang, Yi;Huang, Sanwen;Ma, Yongshuo;Shang, Yi;Huang, Sanwen;Qing, Zhixing;Yang, Peng;Cao, Huifen;Zhang, Yancong;Lin, Kui;Cao, Huifen;Zhang, Yancong;Lin, Kui;Yuan, Zejun;Tang, Zhaoshan;Peng, Qiong;Zhang, Jinbo;Jiang, Wenkai;Ro, Dae-Kyun;Chen, Xiaoya;Chen, Xiaoya

作者机构：

关键词： Macleaya cordata genome;Benzylisoquinoline alkaloids;Secondary metabolism;Sanguinarine;Chelerythrine;Isotopic labeling

期刊名称：MOLECULAR PLANT （ 影响因子：13.164； 五年影响因子：16.357 ）

ISSN： 1674-2052

年卷期： 2017 年 10 卷 7 期

页码：

收录情况： SCI

摘要： The overuse of antibiotics in animal agriculture and medicine has caused a series of potential threats to public health. Macleaya cordata is a medicinal plant species from the Papaveraceae family, providing a safe resource for the manufacture of antimicrobial feed additive for livestock. The active constituents from M. cordata are known to include benzyliso-quinoline alkaloids (BIAs) such as sanguinarine (SAN) and chelerythrine (CHE), but their metabolic pathways have yet to be studied in this non-model plant. The active biosynthesis of SAN and CHE in M. cordata was first examined and confirmed by feeding 13 C-labeled tyrosine. To gain further insights, we de novo sequenced the whole genome of M. cordata, the first to be sequenced from the Papaveraceae family. The M. cordata genome covering 378 Mb encodes 22,328 predicted protein-coding genes with 43.5% being transposable elements. As a member of basal eudicot, M. cordata genome lacks the paleohexaploidy event that occurred in almost all eudicots. From the genomics data, a complete set of 16 metabolic genes for SAN and CHE biosynthesis was retrieved, and 14 of their biochemical activities were validated. These genomics and metabolic data show the conserved BIA metabolic pathways in M. cordata and provide the knowledge foundation for future productions of SAN and CHE by crop improvement or microbial pathway reconstruction.

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