Oocyte exposure to ZnO nanoparticles inhibits early embryonic development through the gamma-H2AX and NF-kappa B signaling pathways

文献类型： 外文期刊

第一作者： Liu, Jing

作者： Liu, Jing;Zhao, Yong;Ge, Wei;Zhang, Pengfei;Liu, Xinqi;Zhang, Weidong;Hao, Yanan;Yu, Shuai;Li, Lan;Chu, Meiqiang;Min, Lingjiang;Shen, Wei;Liu, Jing;Zhao, Yong;Zhang, Hongfu

作者机构：

关键词： ZnO nanoparticles;oocyte stage exposure;embryo-toxicity;gamma-H2AX;NF-kappa B

期刊名称：ONCOTARGET （ 影响因子：5.168； 五年影响因子：5.312 ）

ISSN： 1949-2553

年卷期： 2017 年 8 卷 26 期

页码：

收录情况： SCI

摘要： The impacts of zinc oxide nanoparticles on embryonic development following oocyte stage exposure are unknown and the underlying mechanisms are sparsely understood. In the current investigation, intact nanoparticles were detected in ovarian tissue in vivo and cultured cells in vitro under zinc oxide nanoparticles treatment. Zinc oxide nanoparticles exposure during the oocyte stage inhibited embryonic development. Notably, in vitro culture data closely matched in vivo embryonic data, in that the impairments caused by Zinc oxide nanoparticles treatment passed through cell generations; and both gamma-H2AX and NF-kappaB pathways were involved in zinc oxide nanoparticles caused embryo-toxicity. Copper oxide and silicon dioxide nanoparticles have been used to confirm that particles are important for the toxicity of zinc oxide nanoparticles. The toxic effects of zinc oxide nanoparticles emanate from both intact nanoparticles and Zn2+. Our investigation along with others suggests that zinc oxide nanoparticles are toxic to the female reproductive system [ovaries (oocytes)] and subsequently embryo-toxic and that precaution should be taken regarding human exposure to their everyday use.

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