Doses of Immunogen Contribute to Specificity Spectrums of Antibodies against Aflatoxin

文献类型： 外文期刊

第一作者： Li, Peiwu

作者： Li, Peiwu;Wu, Jing;Tang, Xiaoqian;Zhang, Zhaowei;Zhang, Wen;Zhang, Qi;Li, Peiwu;Tang, Xiaoqian;Zhang, Zhaowei;Zhang, Wen;Zhang, Qi;Li, Peiwu;Tang, Xiaoqian;Zhang, Zhaowei;Zhang, Wen;Zhang, Qi;Li, Peiwu;Tang, Xiaoqian;Zhang, Zhaowei;Zhang, Wen;Zhang, Qi;Wu, Jing;Zhang, Li;Fan, Zhiyong;Yu, Tingting;Jiang, Feng

作者机构：

关键词： specificity spectrums;dose of immuogen;antibodies;aflatoxin

期刊名称：TOXINS （ 影响因子：4.546； 五年影响因子：4.8 ）

ISSN： 2072-6651

年卷期： 2017 年 9 卷 5 期

页码：

收录情况： SCI

摘要： Research about antibody specificity spectra was conducted to develop single-specific antibodies or broad-specific antibodies. Aflatoxins, as one class of high-toxicity mycotoxins, were selected as the research targets to investigate the effect of the immunogen dose on antibody specificity spectra. For this aim, 16 monoclonal antibodies were induced by low or high doses of aflatoxin B-1-BSA, and 34 monoclonal antibodies were induced by low or high doses of aflatoxin M-1-BSA. The specificities of the antibodies induced, whether by aflatoxin B-1 conjugate or aflatoxin M-1 conjugate, indicated that the low dose of the immunogen induced a narrow spectrum of antibody specificity, while the high dose of the immunogen showed an advantage to form a broad spectrum of antibody specificity. Therefore, this report provides important information for the development of new antibodies against small molecules like aflatoxins.

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