Bisphenol A induces lipid metabolism disorder and impairs hepatopancreas of Sesarmops sinensis

文献类型： 外文期刊

第一作者： Zhou, Shangjie

作者： Zhou, Shangjie;Wang, Xiaotian;Huang, Yutong;Zhu, Long;Xu, Xinghong;Zhu, Long;Xu, Xinghong;Liu, Yan;Zheng, Yao;Chu, Pengfei

作者机构：

关键词： Bisphenol a; Lipid metabolism; Lipid deposition; Hepatopancreas; Sesarmops sinensis

期刊名称：MARINE POLLUTION BULLETIN （ 影响因子：4.9； 五年影响因子：5.6 ）

ISSN： 0025-326X

年卷期： 2024 年 208 卷

页码：

收录情况： SCI

摘要： Bisphenol A (BPA) is a chemical that disrupts the endocrine system and may have negative implications on the lipid metabolism of organisms. To ascertain BPA implications on lipid metabolism in the hepatopancreas of Sesarmops sinensis, we exposed S. sinensis to different concentrations of BPA for 14 days. The outcomes manifested that BPA may stimulate hepatopancreas injury and lipid deposition in the hepatopancreas of S. sinensis and lead to the increase of hepatosomatic index (HSI). Transcriptome analysis showed that lipid metabolism-related pathways were significantly enriched in KEGG pathways. BPA exposure also caused disorders in lipid metabolism by altering fatty acid composition and lipid metabolites. The up-regulation of lipid synthesis genes and the alteration of lipid transport genes may be important reasons for the disorder of lipid metabolism. Furthermore, these outcomes provide a fresh point of reference for comprehending the ecotoxicological impacts of BPA on aquatic organisms.

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