Cell adhesion function was altered during the seasonal regression of the seminiferous epithelium in the mink species Neovison vison

文献类型： 外文期刊

第一作者： Zhang, Yufei

作者： Zhang, Yufei;Liu, Shuying;Zhang, Yufei;Liu, Shuying;Zhang, Yufei;Liu, Shuying;Zhu, Yanzhu;Cao, Xiaodong;Cao, Xiaodong;Zhang, Guanhua

作者机构：

关键词： adhering junction; mink; seasonal breeder; testis; testis regression; testis transcriptome

期刊名称：JOURNAL OF ANIMAL SCIENCE （ 影响因子：3.3； 五年影响因子：3.1 ）

ISSN： 0021-8812

年卷期： 2023 年 101 卷

页码：

收录情况： SCI

摘要： Minks are seasonal breeders whose seminiferous epithelium undergoes regression through massive germ cell death, leaving only Sertoli cells and spermatogonial cells in the tubules. However, the molecular mechanisms that control this biological process remain largely unknown. This study describes a transcriptomic analysis of mink testes at various reproductive stages (active, regressing, and inactive). A comparison of seminiferous epithelium at different stages of reproduction shows that cell adhesion is altered during regression. In addition, genes and proteins involved in forming the blood-testis barrier (BTB) were examined in sexually active and inactive minks. The seminiferous epithelium in the testes of sexually inactive minks expressed occludin, but this expression was not discernibly observed in the testes of sexually active minks. There was no discernible expression of CX43 in the seminiferous epithelium in the testes of sexually inactive minks, but CX43 was expressed in the testes of sexually active minks. During the regression process, we observed a remarkable increase in the expression levels of Claudin-11, which is associated with Sertoli-germ cell junctions. In conclusion, these findings suggest a loss of Sertoli-germ cell adhesion, which may regulate postmeiotic cell shedding during testicular regression in mink. Lay Summary Here, we report for the first time the molecular mechanisms of testicular regression in mink. Our results, together with studies on other animals' characteristic reproductive features, identify a cluster of events crucial to the seminiferous epithelium regression process in mammalian seasonal breeders and highlight perspectives unique to the mink. This study aimed to investigate the mechanisms of testicular regression in the mink, which have not been studied previously. The study findings a cluster of events crucial to the seminiferous epithelium regression process in mammalian regular breeders and highlights perspectives unique to the mink.

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