Research and development on lactoferrin and its derivatives in China from 2011-2015

文献类型: 外文期刊

第一作者: Wang, Xiao

作者: Wang, Xiao;Wang, Xiumin;Hao, Ya;Teng, Da;Wang, Jianhua;Wang, Xiao;Wang, Xiumin;Hao, Ya;Teng, Da;Wang, Jianhua

作者机构:

关键词: lactoferrin;lactoferricin;biological function;expression;application

期刊名称:BIOCHEMISTRY AND CELL BIOLOGY ( 影响因子:3.626; 五年影响因子:3.178 )

ISSN: 0829-8211

年卷期: 2017 年 95 卷 1 期

页码:

收录情况: SCI

摘要: Lactoferrin (Lf), a multifunctional glycoprotein, is an important antimicrobial and immune regulatory protein present in neutrophils and most exocrine secretions of mammals. Lactoferricin (Lfcin) is located in the N-terminal region of this protein. In this review, the current state of research into Lf and Lfcin in China is described. Searching with HistCite software in Web Sci located 118 papers published by Chinese researchers from 2011-2015, making China one of the top 3 producers of Lf research and development in the world. The biological functions of Lf and Lfcin are discussed, including antibacterial, antiviral, antifungal, anticarcinogenic, and anti-inflammatory activities; targeted drug delivery, induction of neurocyte, osteoblast, and tenocyte growth, and possible mechanisms of action. The preparation and heterologous expression of Lf in animals, bacteria, and yeast are discussed in detail. Five Lf-related food additive factories and 9 Lf-related health food production companies are certified by the China Food and Drug Administration (CFDA). The latest progress in the generation of transgenic livestock in China, the safety of the use of transgenic animals, and future prospects for the uses of Lf and Lfcin are also covered.

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