Evaluation of glutathione-binding protein A of Haemophilus parasuis as a vaccine candidate in a mouse model

文献类型: 外文期刊

第一作者: Zhang, Yanhe

作者: Zhang, Yanhe;Li, Gang;Xie, Fang;Liu, Siguo;Wang, Chunlai

作者机构:

关键词: Haemophilus parasuis;glutathione-binding protein A (GbpA);vaccine candidate

期刊名称:JOURNAL OF VETERINARY MEDICAL SCIENCE ( 影响因子:1.267; 五年影响因子:1.348 )

ISSN: 0916-7250

年卷期: 2017 年 79 卷 1 期

页码:

收录情况: SCI

摘要: The virulent strains of Haemophilus parasuis are the causative agents of Glasser's disease, which can cause systemic infection and result in polyserositis, meningitis and arthritis. The development of novel, effective vaccines would be beneficial to preventing H. parasuis infections. Here, we report a novel immunogenic protein, glutathione-binding protein A (GbpA), which can elicit a significant humoral antibody response and confer significant protection against challenge with a lethal dose of a highly virulent H. parasuis strain. The H. parasuis strain can be fully eliminated in the immunized mice. The results indicate that GbpA has the potential to be used as an effective component of a new vaccine against H. parasuis.

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