Characterization of the Pathogenesis of H10N3, H10N7, and H10N8 Subtype Avian Influenza Viruses Circulating in Ducks

文献类型： 外文期刊

第一作者： Zhang, Miaomiao

作者： Zhang, Miaomiao;Xu, Jianqing;Zhang, Xiaoyan;Zhang, Miaomiao;Zhang, Xingxing;Xu, Kaidi;Teng, Qiaoyang;Liu, Qinfang;Li, Xuesong;Yang, Jianmei;Chen, Hongjun;Li, Zejun;Teng, Qiaoyang;Liu, Qinfang;Li, Xuesong;Yang, Jianmei;Chen, Hongjun;Li, Zejun

作者机构：

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2016 年 6 卷

页码：

收录情况： SCI

摘要： Three H10 subtype avian influenza viruses were isolated from domestic ducks in China, designated as SH602/H10N8, FJ1761/H10N3 and SX3180/H10N7, with an intravenous pathogenicity index (IVPI) of 0.39, 1.60, and 1.27, respectively. These H10 viruses showed a complex pathology pattern in different species, although full genome characterizations of the viruses could not identify any molecular determinant underlying the observed phenotypes. Our findings describe the pathobiology of the three H10 subtype AIVs in chickens, ducks, and mice. FJ1761/H10N3 evolved E627K and Q591K substitutions in the gene encoding the PB2 protein in infected mice with severe lung damage, suggesting that H10 subtype avian influenza viruses are a potential threat to mammals.

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