The polymorphisms of MHCII beta gene of Trachinotus ovatus and their association with resistance/susceptibility to Photobacterium damsela

文献类型： 外文期刊

第一作者： Zhu, Kecheng

作者： Zhu, Kecheng;Yu, Wenbo;Guo, Huayang;Zhang, Nan;Jiang, Shigui;Zhang, Dianchang;Zhu, Kecheng;Guo, Huayang;Zhang, Nan;Jiang, Shigui;Zhang, Dianchang;Zhu, Kecheng;Zhang, Dianchang;Jiang, Shigui

作者机构：

关键词： Trachinotus ovatus;MHC II beta;Photobacterium damselae;Polymorphisms

期刊名称：AQUACULTURE （ 影响因子：4.242； 五年影响因子：4.723 ）

ISSN： 0044-8486

年卷期： 2018 年 485 卷

页码：

收录情况： SCI

摘要： Trachinotus ovatus is an important economic species in China, with an annual output of over 100,000 tons (FAO). The major histocompatibility complex (MHC) genes, which are a highly polymorphic gene superfamily, play a vital role in the adaptive immune system. In our study, due to the threat caused by Photobacterium damselae, the associations between polymorphisms of exon 2 of MHC II beta and disease resistance/susceptibility were analysed in Trachinotus ovatus. The gene structure of MHC II beta was composed of six exons and five introns in T. ovatus, similar to Hippocampus erectus MHC II beta. Among the forty-three alleles, high levels of polymorphism were found (24.8% of nucleotide positions were variable). In the peptide-binding region (PBR) and non-PBR sites, the value of dN was 6.60 and 12.22 (> 1) times higher than the value of dS, respectively. Six alleles were chosen to calculate their distributions in the high-resistance (HR) and high-susceptibility (HS) groups. The analysis of the associations between alleles and resistance/susceptibility to P. damselae indicated that the TO-DAB-01 allele was associated with immunity to P. damselae and the TO-DAB-04, TO-DAB-05 and TO-DAB-10 alleles were associated with its sensitivity to P. damselae. The results suggest that the diversity of exon 2 of MHC II beta alleles could be used to explore the association between disease susceptibility/resistance and the multiformity of MHC II beta and to achieve the molecular-assisted selection of T. ovatus with enhanced disease resistance.

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