Aroclor 1254 and BDE-47 inhibit dopaminergic function manifesting as changes in locomotion behaviors in zebrafish embryos

文献类型： 外文期刊

第一作者： Tanaka, Yasuaki

作者： Tanaka, Yasuaki;Fujiwara, Mari;Shindo, Asako;Kitazawa, Takio;Teraoka, Hiroki;Shindo, Asako;Yin, Guojun

作者机构：

关键词： Catecholamine;Motor movement;Non-coplanar PCB;PBDE;Zebrafish

期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）

ISSN： 0045-6535

年卷期： 2018 年 193 卷

页码：

收录情况： SCI

摘要： Contamination with polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in the environment is a major concern due to their persistent bioaccumulative toxicity that can disturb neurobehavioral functions including movements. Recently, it was reported that some PBDE including BDE-47 stimulates locomotor activities of zebrafish embryos by unknown mechanism. In this study, motor movements of the zebrafish embryo were used as a model system to evaluate the neuronal toxicity of a non-coplanar PCB-dominant mixture (Aroclor 1254) and BDE-47. Both organohalogens increased tail shaking and rotation of embryos in a concentration-dependent manner. Chemical inhibition and gene knock-down of tyrosine hydroxylase and vesicular monoamine transporter 2 (VMAT2) also induced hyperactivities. Hyperactivities induced by these treatments were all inhibited by supplementation of L-tyrosine and L-dopa, precursors of dopamine synthesis. Both organohalogens reduced dopamine contents and increased the 3,4-dihydroxyphenylacetic acid (DOPAC)/dopamine ratio in whole embryos. The results suggest that functional inhibition of dopaminergic neurons is involved in hyper activities of zebrafish embryos caused by Aroclor 1254 and BDE-47. (C) 2017 Elsevier Ltd. All rights reserved.

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