Pathogenicity and tissue distribution of grass carp reovirus after intraperitoneal administration
文献类型: 外文期刊
第一作者: Liang, Hong-Ru
作者: Liang, Hong-Ru;Li, Yong-Gang;Zeng, Wei-Wei;Wang, Ying-Ying;Wang, Qing;Wu, Shu-Qin;Li, Yong-Gang
作者机构:
关键词: Distribution;GCRV;qRT-PCR
期刊名称:VIROLOGY JOURNAL ( 影响因子:4.099; 五年影响因子:3.719 )
ISSN: 1743-422X
年卷期: 2014 年 11 卷
页码:
收录情况: SCI
摘要: Grass carp reovirus (GCRV) is the causative agent of grass carp hemorrhage and causes significant loss of fingerlings. However, little is known about how the virus is distributed in organs and tissues. The aim of the present study was to investigate the distribution of different GCRV stains in tissues and organs of grass carp. The pathogenicity and tissue distribution of GCRV were monitored after intraperitoneal administration. The study showed a distribution of GCRV in different tissues and organs, particularly in the liver, spleen, kidney, intestine, and muscle, which had a higher number of viral RNA copies during the sixth to ninth days. The kidney had the highest numbers of viral RNA copies, as high as 24000 copies. Until the fourteenth day, nearly no viral RNA copies could be detected. This study defined the virus distribution in different tissues of grass carp inoculated by i.p. and supplied clues for the pathogenesis of GCRV.
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