Bioinformatic Analyses of CCCH-Zinc Finger Family in Zebrafish (Danio rerio)

文献类型: 外文期刊

第一作者: Shui, Yan

作者: Shui, Yan;Xu, Zeng-Hong;Zhou, Xin;Zhou, Xin

作者机构:

关键词: CCCH motif;transcriptional regulation;RNA-binding protein (RBP);zebrafish

期刊名称:PAKISTAN JOURNAL OF ZOOLOGY ( 影响因子:0.831; 五年影响因子:0.768 )

ISSN: 0030-9923

年卷期: 2014 年 46 卷 4 期

页码:

收录情况: SCI

摘要: CCCH-type zinc finger (ZF) proteins are RNA-binding proteins with regulatory functions at all stages of mRNA metabolism. In this study, a genome-wide, survey of CCCH ZF genes in zebrafish was performed for the first time. A total of 51 CCCH genes were identified, but most have not been previously characterized. CCCH motifs and other functional domains in the CCCH protein family were classified and analyzed. Phylogenetic and alignment analyses revealed that the zebrafish CCCH family could be divided into seven groups. Unlike in mammals, CCCH proteins with six CCCH motifs were not found in zebrafish. The fraction of CCCH motifs with C-X7-8-C-X-5-C-X-3-H type (63.5%) was smaller than that found in mouse CCCH proteins (79%).

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