Effects of waterborne cadmium on thyroid hormone levels and related gene expression in Chinese rare minnow larvae
文献类型: 外文期刊
第一作者: Li, Zhi-Hua
作者: Li, Zhi-Hua;Chen, Lu;Wu, Yan-Hua;Li, Ping;Li, Yun-Feng;Ni, Zhao-Hui;Li, Zhi-Hua;Li, Ping;Wu, Yan-Hua
作者机构:
关键词: Cadmium;Chinese rare minnow;Thyroid hormone;Hypothalamic-pituitary-thyroid axis;Gene expression
期刊名称:COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY ( 影响因子:3.228; 五年影响因子:3.289 )
ISSN: 1532-0456
年卷期: 2014 年 161 卷
页码:
收录情况: SCI
摘要: Cadmium is a heavy metal abundant in the environment that can induce endocrine disorder and toxicity in aquatic organisms at low levels. However, its effects on the thyroid system in fish are still unclear. In this study, the thyroid hormone (TH) levels and the expression profiles of genes related to hypothalamic-pituitary-thyroid (HPT) axis, including corticotropin-releasing hormone (crh), thyroid stimulating hormone beta (tsh beta), solute carrier family 5 (sodium iodide symporter) member 5 (slc5a5), thyroglobulin (tg), thyroid hormone receptor alpha (tr alpha) and thyroid hormone receptor beta (tr beta), were determined in whole body of Chinese rare minnow (Gobiogpris rams) larvae after exposure to different levels of Cd2+ (0, 0.5 and 2.5 mg/L) for 4 days. And the 96-h lethal concentration of Cd2+ on rare minnow larvae was determined as 2.59 mg/L. The results showed that crh, slc5a5, tg and tsh beta mRNA levels were significantly up-regulated in the larvae, but the gene expression of tr alpha and tr beta was down-regulated in a concentration-dependent manner. Besides, the This levels decreased in the whole-body of fish, especially the thyroxine (T4) level. The above results indicated that Cd2+ could alter gene expression in the HPT axis that might subsequently contribute to thyroid disruption. (C) 2014 Elsevier Inc. All rights reserved.
分类号:
- 相关文献
作者其他论文 更多>>
-
Regulating heat-induced fibrous whey protein-wheat starch composite emulsion gels as dysphagia food by preheating temperature: Insights from protein-starch interactions
作者:Wang, Zhiming;Zeng, Jiarui;Deng, Yuanyuan;Zhou, Pengfei;Li, Ping;Zhao, Zhihao;Liu, Guang;Zhang, Mingwei;Wang, Zhiming;Zhang, Mingwei;Zhang, Mingwei
关键词:Texture-modified; IDDSI test; Protein aggregates; Gel network structure; Starch digestibility
-
TPT disrupts early embryonic development and glucose metabolism of marine medaka in different salinites
作者:Li, Tengzhou;Liu, Bin;Xing, Shaoying;Liu, Ling;Li, Ping;Li, Zhi-Hua;Li, Luoxin
关键词:Oryzias melastigma; Triphenyltin; Salinity; Insulin signaling pathway
-
The synergistic role of sludge conditioner FeCl3/Rice husk on co-combustion with coal gangue: Thermaldynamic behavior, gases pollutants control and bottom ash stabilization
作者:Li, Jixin;He, Yiyang;Wang, Xin;Cao, Xiao;Yang, Haiyan;Chen, Lu;Xu, Suyun;Wen, Haifeng;Gu, Lin;Zhang, Hanlin
关键词:Coal gangue; Dewatered sludge; Co-combustion; TG-FTIR; Kinetics
-
Impact of homogenization methods on the interfacial protein composition and stability of peanut oil body emulsion with sodium caseinate and maltodextrin
作者:Lin, Zihui;Zhou, Pengfei;Deng, Yuanyuan;Liu, Guang;Li, Ping;Zeng, Jiarui;Zhang, Yan;Tang, Xiaojun;Zhao, Zhihao;Zhang, Mingwei;Lin, Zihui
关键词:Peanut oil body; Homogenization methods; Emulsion; Interfacial protein; Stability
-
Influence of Mikania micrantha Kunth Flavonoids on Composition of Soil Microbial Community
作者:Yang, Qilin;Cui, Wenyang;Guan, Zijun;Wang, Zhenzhen;Jahan, Israt;Li, Ping;Yan, Jian;Qin, Feng;Qiao, Xi;Liu, Bo
关键词:
Mikania micrantha ; flavonoids; soil microbial communities; arbuscular mycorrhizal fungi (AMF); invasive plant management -
Cyclic trace enzymatic hydrolysis pretreatment enhances brown rice: Cooking and taste
作者:Deng, Yuanyuan;Zhou, Pengfei;Li, Ya;Li, Ping;Zhao, Zhihao;Wang, Jiajia;Zhong, Lihuang;Liu, Guang;Zhang, Mingwei;Zeng, Jiarui;Liu, Dong
关键词:Brown rice; Cyclic trace enzymatic hydrolysis; Quality improvement
-
Transcriptome analysis and functional study of phospholipase A2 in Galleria mellonella larvae lipid metabolism in response to envenomation by an ectoparasitoid, Iseropus kuwanae
作者:Zhu, Hanqi;Liang, Xinhao;Ding, Jianhao;Wang, Jinzheng;Li, Ping;Zhou, Weihong;Wang, Jun;Wu, Fu-an;Sheng, Sheng;Li, Ping;Zhou, Weihong;Wang, Jun;Wu, Fu-an;Sheng, Sheng
关键词:ectoparasitoids; Galleria mellonella; Iseropus kuwanae; lipid metabolism; the greater wax moth; transcriptome; wasp development