Six New Tetraprenylated Alkaloids from the South China Sea Gorgonian Echinogorgia pseudossapo

文献类型： 外文期刊

第一作者： Sun, Zhang-Hua

作者： Sun, Zhang-Hua;Cai, Ying-Hong;Tang, Gui-Hua;Luo, Hai-Bin;Yin, Sheng;Fan, Cheng-Qi

作者机构：

关键词： gorgonian;Echinogorgia pseudossapo;tetraprenylated alkaloids;phosphodiesterases

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN： 1660-3397

年卷期： 2014 年 12 卷 2 期

页码：

收录情况： SCI

摘要： Six new tetraprenylated alkaloids, designated as malonganenones L-Q (1-6), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China. The structures of 1-6 featuring a methyl group at N-3 and a tetraprenyl chain at N-7 in the hypoxanthine core were established by extensive spectroscopic analyses. Compounds 1-6 were tested for their inhibitory activity against the phosphodiesterases (PDEs)-4D, 5A, and 9A, and compounds 1 and 6 exhibited moderate inhibitory activity against PDE4D with IC50 values of 8.5 and 20.3 mu M, respectively.

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[1]Chemical constituents of gorgonian Verrucella umbraculum from the South China Sea. Sun, Ling-Ling,Shao, Chang-Lun,Wang, Chang-Yun,Mei, Wen-Li,Dai, Hao-Fu,Huang, Hui. 2010

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