Effect of 17 alpha-methyltestosterone (MT) on oxidation stress in the liver of juvenile GIFT tilapia, Oreochromis niloticus

文献类型： 外文期刊

第一作者： Zheng, Yao

作者： Zheng, Yao;Qu, Jianhong;Qiu, Liping;Fan, Limin;Meng, Shunlong;Song, Chao;Bing, Xuwen;Chen, Jiazhang;Zheng, Yao;Qu, Jianhong;Qiu, Liping;Fan, Limin;Meng, Shunlong;Song, Chao;Bing, Xuwen;Chen, Jiazhang;Zheng, Yao;Bing, Xuwen;Chen, Jiazhang

作者机构：

关键词： 17 alpha-Methyltestosterone;Antioxidant enzyme;Genotoxicity;Oreochromis niloticus;Oxidative stress

期刊名称：SPRINGERPLUS （ 影响因子：1.13； 五年影响因子：1.29 ）

ISSN： 2193-1801

年卷期： 2016 年 5 卷

页码：

收录情况： SCI

摘要： The normal dose of 17 alpha-methyltestosterone (MT) used in fish farming was 60 mg/L, and now the analysis of residual androgens was carried out in waste water obtained from the Beijing area, which could be detected in levels ranging from 4.1 to 7.0 ng/L. For the purpose of aquatic early warning, the present study clearly demonstrated that chronic exposure by higher concentration of MT than environmental relevant concentrations could trigger oxidative stress response to juvenile tilapia by modulating hepatic antioxidant enzyme activities and gene transcription. Some antioxidative parameters (T-GSH, GSH/GSSG and MDA) were significant decreased under 0.5 mg/L MT exposure at 7 and 14 days. Some antioxidant enzymes (SOD, CAT and GST) and transcriptional changes (sod and cat) were revealed significant decreases for MT treated groups at 7 days. Total antioxidant capacity was significant increased only in 5 mg/L MT exposure groups, but GR activities were not affected all through the whole exposure period. Almost all of the antioxidant enzymatic genes detected in the present study were showed significant increments for MT exposure both at 14 and 21 days, and the genotoxicity profile of antioxidant enzymatic genes were revealed dose-dependent manner. This study presented evidence that MT could result in oxidative stress response in the early stages of GIFT tilapia.

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