文献类型： 外文期刊
第一作者： Yu, Jin-Hai
作者： Yu, Jin-Hai;Yu, Shu-Juan;Liu, Kai-Lu;Wang, Chao;Zhang, Hua;Liu, Chao;Sun, Jin-yue
作者机构：
关键词： Ganoderma lingzhi; Lingzhi; Ergostane; Steroids; Cytotoxicity
期刊名称：STEROIDS （ 影响因子：2.668； 五年影响因子：2.692 ）
ISSN： 0039-128X
年卷期： 2021 年 165 卷
页码：
收录情况： SCI
摘要： Two new ergostane-type steroids (1 and 2) have been isolated from the fruiting body of a medicinal macro fungus Ganoderma lingzhi. The structures including the absolute configurations of them were elucidated by a combination of different spectroscopic analyses especially C-13 NMR and ECD calculations. Compound 2 features an unusual 1,2-dioxolane moiety. Our bioassays revealed that the two steroids showed remarkable cytotoxicity against human A549 (lung) and MCF-7 (breast) tumor cell lines, with IC50 values ranging from 5.15 to 8.57 mu g/mL.
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