A novel monoclonal antibody associated with glucoside kills gastric adenocarcinoma AGS cells based on glycosylation target

文献类型： 外文期刊

第一作者： Xu, Heng

作者： Xu, Heng;Xu, Heng;Dun, Boying;Mysona, David;She, Jin-Xiong;Liu, Beiyi;Ma, Rong;Ma, Rong;Ma, Rong

作者机构：

关键词： cancer; cell death; glucoside; glycosylation; monoclonal antibody

期刊名称：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE （ 影响因子：5.295； 五年影响因子：5.565 ）

ISSN： 1582-1838

年卷期： 2022 年 26 卷 18 期

页码：

收录情况： SCI

摘要： Glycosylation results in the production of glycans which are required for certain proteins to function. These glycans are also present on cell surfaces where they help maintain cell membrane integrity and are a key component of immune recognition. As such, cancer has been shown to alter glycosylation to promote tumour proliferation, invasion, angiogenesis, and immune envasion. Currently, there are few therapeutic monoclonal antibodies (mAb) which target glycosylation alterations in cancer. Here, we report a novel mAb associated with a glucoside, mAb 201E4, which is able induce cancer cell death and apoptosis based on a specific glycosylation target. This mAb evokes cancer cell death in vitro via caspase, fas, and mitochondrial associated apoptotic pathways. The efficacy of this mAb was further confirmed in vivo as treatment of mice with mAb 201E4 resulted in potent tumour shrinkage. Finally, the antibody was proven to be specific to glycosylation alterations in cancer and have no binding to normal tissues. This data indicates that mAb 201E4 successfully targets glycosylation alterations in neoplasms to induce cancer cell death, which may provide a new strategy for therapy in cancer.

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