Structural characterization of a soluble polysaccharide SSPS1 from soy whey and its immunoregulatory activity in macrophages
文献类型： 外文期刊
第一作者： Guan, Xuefang
作者： Guan, Xuefang;Wang, Qi;Lin, Bin;Sun, Meiling;Zheng, Qi;Huang, Juqing;Lai, Gongti;Guan, Xuefang;Wang, Qi;Huang, Juqing
作者机构：
关键词： Polysaccharide; Immunoregulatory; Soy whey
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.025； 五年影响因子：7.626 ）
ISSN： 0141-8130
年卷期： 2022 年 217 卷
页码：
收录情况： SCI
摘要： A soluble soybean polysaccharide SSPS1 with a molecular weight of 2737 kDa was extracted and purified from soy whey. SSPS1 was composed of glucose (97.3 %) and a small amount of mannose (2.7 %). Structural analysis results suggested that SSPS1 had a -> 6)-alpha-D-Glcp-(1 -> glucan structure, with a trace amount of alpha-D-Glcp-(1 -> connected to the main chain via O-3. In vitro immunological experiments suggested that SSPS1 enhanced the growth rate and phagocytic activity of RAW 264.7 macrophages. In addition, SSPS1 stimulated the secretion of cytokines (TNF-alpha, INF-beta, IL-6 and IL-1 beta) as well as nitric oxide (NO) production through upregulating the expression of the related genes and proteins in RAW 264.7 cells. This study provided a new method for efficient utilization of soy whey, and the results indicate that SSPS1 extracted from soy whey could be used as a novel immunomodulator.
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