miR-1307/BRCA1 axis mediated oxidative stress promotes apoptosis of sow ovarian granulosa cells

文献类型： 外文期刊

第一作者： Wang, Siqi

作者： Wang, Siqi;Li, Jian;Du, Xing;Zhang, Lifan;Cao, Shaoxian;Li, Qifa;Cao, Shaoxian

作者机构：

关键词： BRCA1; MiR-1307; Sow fertility; Granulosa cell apoptosis; Oxidative stress

期刊名称：ANIMAL REPRODUCTION SCIENCE （ 影响因子：3.3； 五年影响因子：2.6 ）

ISSN： 0378-4320

年卷期： 2025 年 279 卷

页码：

收录情况： SCI

摘要： Breast cancer associated gene 1 (BRCA1) mutation and consequential reduction in transcription cause cancer, predominantly in the breast and ovarian tissues. However, its noncancer-related functions in ovarian tissues remain largely unknown. Here, we report BRCA1 is strongly involved in sow granulosa cell (sGC) apoptosis and cycle, and is targeted and inhibited by the proapoptotic miR-1307. BRCA1 is highly abundant in sGCs, and up-regulated during sow follicular development, but weakly expressed in atretic follicles, indicating a close correlation with sow follicular development and atresia. A loss-of-function assay showed that BRCA1 suppresses sGC apoptosis and promotes cell cycle progression. Furthermore, miR-1307 is a pro-apoptotic factor that inhibits BRCA1 by targeting the 3 ' UTR of the latter. In addition, the miR-1307 and BRCA1 axis can be activated by oxidative stress (OS), which is related to the transcriptional activation of miR-1307 by FoxO3, a transcription factor activated by OS. In conclusion, this study provides a basis for understanding the role of BRCA1 in sow reproduction and a theoretical target for improving sow fertility.

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