Identification of Candidate Genes Regulating Carcass Depth and Hind Leg Circumference in Simmental Beef Cattle Using Illumina Bovine Beadchip and Next-Generation Sequencing Analyses

文献类型： 外文期刊

第一作者： Bordbar, Farhad

作者： Bordbar, Farhad;Xu, Lingyang;Li, Junya;Zhang, Lupei;Bordbar, Farhad;Mohammadabadi, Mohammadreza;Jensen, Just

作者机构：

关键词： genome-wide association study; carcass depth; hind leg circumference; next-generation sequencing; Simmental beef cattle

期刊名称：ANIMALS （ 影响因子：3.231； 五年影响因子：3.312 ）

ISSN： 2076-2615

年卷期： 2022 年 12 卷 9 期

页码：

收录情况： SCI

摘要： Genome-wide association studies are a robust means of identifying candidate genes that regulate economically important traits in farm animals. The aim of this study is to identify single-nucleotide polymorphisms (SNPs) and candidate genes potentially related to carcass depth and hind leg circumference in Simmental beef cattle. We performed Illumina Bovine HD Bead-chip (similar to 670 k SNPs) and next-generation sequencing (similar to 12 million imputed SNPs) analyses of data from 1252 beef cattle, to which we applied a linear mixed model. Using a statistical threshold (p = 0.05/number of SNPs identified) and adopting a false discovery rate (FDR), we identified many putative SNPs on different bovine chromosomes. We identified 12 candidate genes potentially annotated with the markers identified, including CDKAL1 and E2F3, related to myogenesis and skeletal muscle development. The identification of such genes in Simmental beef cattle will help breeders to understand and improve related traits, such as meat yield.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序