Pharmacokinetics, withdrawal period and risk assessment of enrofloxacin in the northern snakehead (Channa argus) following bath administration

文献类型： 外文期刊

第一作者： Zhang, Meiling

作者： Zhang, Meiling;Zheng, Guangming;Yin, Yi;Zhou, Hao;Ma, Lisha;Li, Lichun;Lin, Jiawei;Liu, Shugui;Zhao, Cheng;Dai, Xiaoxin;Wei, Linting;Shan, Qi;Shan, Qi

作者机构：

关键词： enrofloxacin; northern snakehead; pharmacokinetics; risk assessment; withdrawal period

期刊名称：JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS （ 影响因子：1.3； 五年影响因子：1.4 ）

ISSN： 0140-7783

年卷期： 2023 年

页码：

收录情况： SCI

摘要： Enrofloxacin (ENR) is widely used in aquaculture practice, but little is known about its pharmacokinetic, withdrawal period and dietary risk in fish via bath administration. The purpose of this study was to provide data support for the use of ENR bath therapy in the northern snakehead (Channa argus). The pilot study was carried out to evaluate the therapy concentrations of ENR in northern snakehead with immersion concentrations ranged from 5 to 40 mg/L for 6 h. Based on results of the pilot study, an ENR immersion concentration of 20 mg/L was used for the formal experiment. At this dose, the peak concentrations of ENR in plasma, muscle plus skin, liver and kidney were 4.85, 4.55, 3.87 and 7.42 mu g/mL (or g), respectively. According to the AUC(0-infinity) values, the distribution of ENR in northern snakehead followed the order of kidney > plasma > liver > muscle + skin. The elimination of ENR in northern snakehead was very slow, the half-lives (T-1/2 lambda z) were up to 90.31, 85.5, 104.56 and 120.9 h in plasma, muscle plus skin, liver and kidney, respectively. Ciprofloxacin (CIP) was not detected in any samples in the pilot study and was only occasionally detected in muscle plus skin and liver samples in formal experiment. Based on the calculated PK/PD index AUC/MIC and C-max/MIC, the current bath treatment regimen will have a good therapeutic effect on infections caused by bacteria with MIC below 0.6 mu g/mL. The dietary risk assessment suggested that there was a dietary risk (Hazard Quotients > 10%) until day 6 after bath treatment. It is mandatory for ENR to maintain a withdrawal period of at least 450 degrees C-day in northern snakehead after bath treatment ceased.

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