Identification and yield of metabolites of chlorinated paraffins incubated with chicken liver microsomes: Assessment of their potential to convert into metabolites

文献类型： 外文期刊

第一作者： Huang, Xiaomei

作者： Huang, Xiaomei;Xu, Kaihang;Zhao, Yarong;Wang, Xu;Huang, Xiaomei;Xu, Kaihang;Zhao, Yarong;Wang, Xu;Huang, Xiaomei;Xu, Kaihang;Wang, Xu;Lyu, Lina

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关键词： Short-chain chlorinated paraffin; Medium-chain chlorinated paraffin; Long-chain chlorinated paraffin; Metabolic elimination; Hydroxylated metabolite

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：13.6； 五年影响因子：12.7 ）

ISSN： 0304-3894

年卷期： 2023 年 455 卷

页码：

收录情况： SCI

摘要： Chlorinated paraffins (CPs) are emerging environmental pollutants. Although metabolism has been shown to affect the differential accumulation of short-chain (SCCPs), medium-chain (MCCPs) and long-chain (LCCPs) CPs in birds, CP metabolites have rarely been reported and the extent to which they are formed is still unclear. In this study, single and mixed CP standards were incubated with chicken liver microsomes in vitro to study the gen-eration of CP metabolites. Putative aldehyde/ketone and carboxylic acid metabolites identified by mass spec-troscopy data were shown to be false positive results. Phase I metabolism of CPs first formed monohydroxylated ([M-Cl+OH]) and then dihydroxylated ([M-2Cl+2OH]) products. The yields of monohydroxylated metabolites of CPs decreased with increasing carbon chain length and chlorine content at the initial stage of reaction. Notably, the yield of monohydroxylated metabolites of SCCPs with 51.5% Cl content reached 21%, and that of 1,2,5,6,9,10-hexachlorodecane (C10H16Cl6) was as high as 71%. Thus, monohydroxy metabolites of CPs in birds should not be ignored, especially those of SCCPs. This study provides important data that could support im-provements to the ecological/health risk assessment of CPs.

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