Advances in molecular epidemiology and detection methods of pseudorabies virus

文献类型： 外文期刊

第一作者： Zhuang, Linlin

作者： Zhuang, Linlin;Yang, Jianbo;Liu, Qingxin;Shen, Qiuping;Zhuang, Linlin;Zhao, Ying;Zhang, Yu;Zhuang, Linlin;Zhao, Ying;Zhang, Yu;Gong, Jiansen;Shen, Jingyi

作者机构：

关键词： Pseudorabies virus; Epidemiology; Vaccines; Molecular detection methods

期刊名称：DISCOVER NANO （ 影响因子：4.5； 五年影响因子：4.5 ）

ISSN：

年卷期： 2025 年 20 卷 1 期

页码：

收录情况： SCI

摘要： Pseudorabies (PR), a highly contagious disease caused by the pseudorabies virus (PRV), represents a significant threat to the global swine industry. Despite the success of developed countries in controlling the PRV epidemic through swine pseudorabies eradication programs, wild boars, as a potential source of infection, still require sustained attention and effective control measures. Concurrently, there has been considerable global attention directed towards cases of PRV infection in humans. In consideration of the aforementioned factors, this paper presents a comprehensive review of recent developments in the PRV genome, epidemiology, vaccine research, and molecular detection methods. The epidemiology section presents an analysis of the transmission routes, susceptible animal groups, and geographic distribution of PRV, as well as an examination of the trend of the epidemic in recent years. In the field of vaccine research, the current development of genetically engineered vaccines is emphasized, and the immunogenicity and safety of vaccines are discussed. Moreover, the molecular detection techniques utilized to identify PRV, including immunological methods, nucleic acid detection methods, biosensors, and so forth, are presented in a systematic manner. Finally, this paper presents a comprehensive discussion of the current status of PRV-related research and offers insights into future directions, with the aim of providing a foundation for the scientific prevention and control of PRV.

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