Supplementation of quinoa peptides alleviates colorectal cancer and restores gut microbiota in AOM/DSS-treated mice

文献类型： 外文期刊

第一作者： Fan, Xin

作者： Fan, Xin;Guo, Huimin;Teng, Cong;Yang, Xiushi;Qin, Peiyou;Ren, Guixing;Fan, Xin;Ren, Guixing;Guo, Huimin;Fan, Xin;Blecker, Christophe;Guo, Huimin;Richel, Aurore;Zhang, Lizhen;Ren, Guixing

作者机构：

关键词： Quinoa protein hydrolysate; Gastrointestinal digestion; Short chain fatty acids; Microbial dysbiosis; Colon cancer

期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）

ISSN： 0308-8146

年卷期： 2023 年 408 卷

页码：

收录情况： SCI

摘要： Quinoa protein hydrolysate has been previously reported to exert anti-cancer effects in cultured colon cancer cells. Here, we investigated the effect of quinoa protein and its hydrolysate on an azoxymethane/dextran sulfate sodium (AOM/DSS)-induced mouse model of colorectal cancer (CRC) and examined its underlying mechanism using gut microbiota analysis and short chain fatty acids (SCFAs) production analysis. Our results showed that quinoa protein or its hydrolysate mitigated the clinical symptoms of CRC and increased SCFAs contents in colon tissues. Moreover, administration of quinoa protein or its hydrolysate partially alleviated gut microbiota dys-biosis in CRC mice by decreasing the abundance of pathogenic bacteria and increasing the abundance of pro-biotics. Additionally, PICRUSt analysis revealed that the functional profile of gut microbiota in the quinoa protein treated groups was more similar to that of the control group. These findings indicated that the modu-lation of gut microbiota by quinoa protein diet intervention may ameliorate AOM/DSS-induced CRC.

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