Disrupted Microbiota of Colon Results in Worse Immunity and Metabolism in Low-Birth-Weight Jinhua Newborn Piglets

文献类型： 外文期刊

第一作者： Li, Jiaheng

作者： Li, Jiaheng;Lou, Fangfang;Zhang, Xiaojun;Hu, Xujin;Tu, Pingguang;Du, Xizhong;Li, Jiaheng;Wei, Zeou;Duan, Jiujun;Luo, Chengzeng;Liu, Lei;Zhong, Ruqing;Chen, Liang;Zhang, Hongfu;Li, Jiaheng;Wei, Zeou

作者机构：

关键词： Jinhua newborn piglet; low-birth-weight; microbiome; transcriptome; glucose metabolism; immunity; short chain fatty acids

期刊名称：MICROORGANISMS （ 影响因子：4.1； 五年影响因子：4.5 ）

ISSN：

年卷期： 2024 年 12 卷 7 期

页码：

收录情况： SCI

摘要： The Jinhua pig is well known in China due to its delicious meat. However, because of large litter size, low birth weight always happens. This experiment used this breed as a model to research bacterial evidence leading to growth restriction and provide a possible solution linked to probiotics. In this experiment, the differences in organs indexes, colonic morphology, short chain fatty acid (SCFA) concentrations, microbiome, and transcriptome were detected between piglets in the standard-birth-weight group (SG) and low-birth-weight group (LG) to find potential evidence leading to low birth weight. We found that LG piglets had a lower liver index (p < 0.05), deeper colonic crypt depth (p < 0.05), fewer goblet cells (p < 0.05), and more inflammatory factor infiltration. In addition, differentially expressed genes (DEGs) were mainly enriched in B-cell immunity and glucose metabolism, and LG piglets had lower concentrations of SCFAs, especially butyrate and isobutyrate (p < 0.05). Finally, most of the significantly differentially abundant microbes were fewer in LG piglets, which affected DEG expressions and SCFA concentrations further resulting in worse energy metabolism and immunity. In conclusion, colonic disrupted microbiota may cause worse glucose metabolism, immunity, and SCFA production in LG piglets, and beneficial microbes colonized in SG piglets may benefit these harmful changes.

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