The interactions of flaviviruses with cellular receptors: Implications for virus entry

文献类型： 外文期刊

第一作者： Anwar, Muhammad Naveed

作者： Anwar, Muhammad Naveed;Rehman, Zaib Ur;Malik, Muhammad Irfan;Hameed, Muddassar;Wahaab, Abdul;Li, Zongjie;Liu, Ke;Li, Beibei;Qiu, Yafeng;Ma, Zhiyong;Wei, Jianchao;Abid, Muhammad;Akhtar, Raheela;Tayyub, Muhammad;Shahzad, Muhammad Khurram;Mubeen, Hadia;Qadir, Muhammad Shahzad;Khan, Shahzad Akbar

作者机构：

关键词： Flaviviruses; Cellular receptors; Attachment; Internalization; Membrane fusion

期刊名称：VIROLOGY （ 影响因子：3.513； 五年影响因子：3.479 ）

ISSN： 0042-6822

年卷期： 2022 年 568 卷

页码：

收录情况： SCI

摘要： Flaviviruses are a group of enveloped viruses that enter the host cells through receptor-mediated endocytosis. The entry of flaviviruses into the cells is a multi-step process which involves several host factors that trigger the uptake of the virus. The initial step in the virus life cycle is the interactions between viral envelope proteins and the specific receptors on the surface of host cell. To date, several receptors have been identified such as glycosaminoglycans, tight junction proteins, laminin receptor and phosphatidylserine receptors. Moreover, the viruses may utilize integrins and C-type lectin receptors on the surface of host cells as the initial attachment factors. This mini-review will focus on recent progresses in the understanding of virus attachment, internalization, and membrane fusion with specific emphasis on the cellular receptors.

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