Inflammatory Mechanism of Brucella Infection in Placental Trophoblast Cells

文献类型： 外文期刊

第一作者： Xiao, Yu

作者： Xiao, Yu;Li, Mengjuan;Guo, Xiaoyi;Zeng, Hui;Shuai, Xuehong;Guo, Jianhua;Huang, Qingzhou;Jiao, Hanwei;Chu, Yuefeng;Zhou, Bo;Liu, Jun;Wen, Jake;Jiao, Hanwei

作者机构：

关键词： Brucella; trophoblast; pathogenesis; inflammatory response; infection mechanism

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：6.208； 五年影响因子：6.628 ）

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年卷期： 2022 年 23 卷 21 期

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收录情况： SCI

摘要： Brucellosis is a severe zoonotic infectious disease caused by the infection of the Brucella, which is widespread and causes considerable economic losses in underdeveloped areas. Brucella is a facultative intracellular bacteria whose main target cells for infection are macrophages, placental trophoblast cells and dendritic cells. The main clinical signs of Brucella infection in livestock are reproductive disorders and abortion. At present, the pathogenesis of placentitis or abortion caused by Brucella in livestock is not fully understood, and further research on the effect of Brucella on placental development is still necessary. This review will mainly introduce the research progress of Brucella infection of placental trophoblast cells as well as the inflammatory response caused by it, explaining the molecular regulation mechanism of Brucella leading to reproductive system disorders and abortion, and also to provide the scientific basis for revealing the pathogenesis and infection mechanism of Brucella.

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