Transcriptome analysis endoplasmic reticulum-stress response in Litopenaeus vannamei hemocytes

文献类型： 外文期刊

第一作者： Chen, Yi-Hong

作者： Chen, Yi-Hong;Li, Bin-Bin;Fan, Jin-Quan;Hong, Qian-Ming;Yan, Ze-Yu;Yang, Xin-Jun;Lu, Ke-Cheng;Chen, Guo-Liang;Li, Ming;Huang, Wen;Chen, Yi-Hong;Li, Bin-Bin;Fan, Jin-Quan;Hong, Qian-Ming;Yan, Ze-Yu;Yang, Xin-Jun;Lu, Ke-Cheng;Chen, Guo-Liang

作者机构：

关键词： Litopenaeus vannamei; Environmental stress; ER-Stress; Thapsigargin; Prophenoloxidase activating enzyme 2 (PPAE2)

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.622； 五年影响因子：4.799 ）

ISSN： 1050-4648

年卷期： 2022 年 124 卷

页码：

收录情况： SCI

摘要： Numerous studies have proved that endoplasmic reticulum (ER)-stress is an important cause of aquatic animal diseases. Therefore, for effectively preventing and controlling aquatic animal diseases, a systematic and in-depth understanding of the environmental stress response in aquatic animals is necessary. In present study, the influence of ER-stress in Litopenaeus vannamei was investigated using Illumina HiSeq based RNA-Seq. Comparing to the cDNA library of hemocytes treated with DMSO in L. vannamei, 286 unigenes were significantly upregulated and 473 unigenes were significantly down-regulated in the Thapsigargin treated group. KEGG analysis indicated that the differentially expressed genes (DEGs) are mainly related to ER-stress, immune as well as metabolism. Besides the classical ER-stress response pathways, the regulation of cell cycle and DNA replication are also important measures of ER-stress response. It has been suggested that the influence of ER-stress on immune genes might be an important factor in environmental stress inducing shrimp disease. Our investigation exhibited that immune-related DEG Prophenoloxidase activating enzyme 2 (LvPPAE2) roled in anti-pathogen immunity of shrimp. This study provides a solid foundation for uncovering the environmental adaptation response and especially its relationship with L. vannamei immune system.

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