Gut-Liver Axis as a Therapeutic Target for Drug-Induced Liver Injury

文献类型： 外文期刊

第一作者： Tao, Wenjing

作者： Tao, Wenjing;Fan, Qiwen;Wei, Jintao

作者机构：

关键词： drug-induced liver injury; gut-liver axis; gut microbiota; metabolites; bile acid

期刊名称：CURRENT ISSUES IN MOLECULAR BIOLOGY （ 影响因子：3.1； 五年影响因子：3.3 ）

ISSN： 1467-3037

年卷期： 2024 年 46 卷 2 期

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收录情况： SCI

摘要： Drug-induced liver injury (DILI) is a liver disease that remains difficult to predict and diagnose, and the underlying mechanisms are yet to be fully clarified. The gut-liver axis refers to the reciprocal interactions between the gut and the liver, and its homeostasis plays a prominent role in maintaining liver health. It has been recently reported that patients and animals with DILI have a disrupted gut-liver axis, involving altered gut microbiota composition, increased intestinal permeability and lipopolysaccharide translocation, decreased short-chain fatty acids production, and impaired bile acid metabolism homeostasis. The present review will summarize the evidence from both clinical and preclinical studies about the role of the gut-liver axis in the pathogenesis of DILI. Moreover, we will focus attention on the potential therapeutic strategies for DILI based on improving gut-liver axis function, including herbs and phytochemicals, probiotics, fecal microbial transplantation, postbiotics, bile acids, and Farnesoid X receptor agonists.

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