Immunoassays and Emerging Analytical Techniques of Fipronil and its Metabolites for Food Safety: A Review

文献类型： 外文期刊

第一作者： Li, Peipei

作者： Li, Peipei;Wang, Jing;Jin, Maojun;Li, Peipei;Wang, Jing;Jin, Maojun;Abd El-Aty, A. M.;Abd El-Aty, A. M.;Jiang, Haiyang;Shen, Jianzhong;Wang, Zhanhui;Wen, Kai;Jiang, Haiyang;Shen, Jianzhong;Wang, Zhanhui;Wen, Kai;Li, Jia;Wang, Shuting;Hammock, Bruce D.;Hammock, Bruce D.

作者机构：

关键词： fipronil; metabolites; toxicity; analyticalstrategies; food safety; review

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）

ISSN： 0021-8561

年卷期： 2024 年 72 卷 4 期

页码：

收录情况： SCI

摘要： Fipronil, classified as a phenylpyrazole insecticide, is utilized to control agricultural, public health, and veterinary pests. Notably, its unique ecological fate involves degradation to toxic metabolites, which poses the risk of contamination in water and foodstuffs and potential human exposure through the food chain. In response to these concerns, there is a pressing need to develop analytical methodologies for detecting fipronil and its metabolites. This review provides a concise overview of the mode of action, metabolism, and toxicology of fipronil. Additionally, various detection strategies, encompassing antibody-based immunoassays and emerging analytical techniques, such as fluorescence assays based on aptamer/molecularly imprinted polymer/fluorescent probes, electrochemical sensors, and Raman spectroscopy, are thoroughly reviewed and discussed. The focus extends to detecting fipronil and its metabolites in crops, fruits, vegetables, animal-derived foods, water, and bodily fluids. This comprehensive exploration contributes valuable insights into the field, aiming to foster the development and innovation of more sensitive, rapid, and applicable analytical methods.

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