Physiological and Molecular Mechanisms of Lepidopteran Insects: Genomic Insights and Applications of Genome Editing for Future Research

文献类型： 外文期刊

第一作者： Niu, Dongsheng

作者： Niu, Dongsheng;Zhao, Qing;Xu, Linbo;Lin, Kejian;Niu, Dongsheng;Zhao, Qing;Xu, Linbo;Lin, Kejian;Niu, Dongsheng;Zhao, Qing;Xu, Linbo;Lin, Kejian;Niu, Dongsheng;Zhao, Qing;Xu, Linbo;Lin, Kejian

作者机构：

关键词： lepidopteran insects; insecticide resistance; functional genomics; gene editing; CRISPR/Cas9; pest management; genomic data; sustainable agriculture

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：4.9； 五年影响因子：5.7 ）

ISSN： 1661-6596

年卷期： 2024 年 25 卷 22 期

页码：

收录情况： SCI

摘要： Lepidopteran insects are a major threat to global agriculture, causing significant crop losses and economic damage. Traditional pest control methods are becoming less effective due to the rapid evolution of insecticide resistance. This study explores the current status and genomic characteristics of 1315 Lepidopteran records, alongside an overview of relevant research, utilizing advanced functional genomics techniques, including RNA-seq and CRISPR/Cas9 gene-editing technologies to uncover the molecular mechanisms underlying insecticide resistance. Our genomic analysis revealed significant variability in genome size, assembly quality, and chromosome number, which may influence species' biology and resistance mechanisms. We identified key resistance-associated genes and pathways, including detoxification and metabolic pathways, which help these insects evade chemical control. By employing CRISPR/Cas9 gene-editing techniques, we directly manipulated resistance-associated genes to confirm their roles in resistance, demonstrating their potential for targeted interventions in pest management. These findings emphasize the value of integrating genomic data into the development of effective and sustainable pest control strategies, reducing reliance on chemical insecticides and promoting environmentally friendly integrated pest management (IPM) approaches. Our study highlights the critical role of functional genomics in IPM and its potential to provide long-term solutions to the growing challenge of Lepidopteran resistance.

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