Structural Elucidation and Anti-Tumor Activity of a Polysaccharide (CP2-S) from Cordyceps militaris Fruit Bodies

文献类型： 外文期刊

第一作者： Zhu, Lina

作者： Zhu, Lina;Wang, Jinyan;Tang, Qingjiu;Liu, Yanfang;Zhu, Lina

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关键词： Cordyceps militaris; polysaccharide; structure; anti-tumor

期刊名称：POLYMERS （ 影响因子：4.7； 五年影响因子：4.9 ）

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年卷期： 2024 年 16 卷 14 期

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收录情况： SCI

摘要： A polysaccharide (CP2-S), consisting of glucose with a weight average molecular weight of 5.9 x 10(6), was purified from the fruit bodies of Cordyceps militaris. In this work, the corresponding structure and anti-tumor activity in vivo were investigated. Methylation and NMR analysis revealed that CP2-S was composed of a -> 4)-alpha-D-Glcp-(1 -> backbone with partial substitution occurring at O-6 by T-linked alpha-D-Glcp in every ten residues, which has not been reported in previous reports. In vivo anti-tumor experiments showed that CP2-S could inhibit the growth of Lewis lung carcinoma in mice. Tumor inhibition rates were 17.8%, 24.5%, and 29.5% at dosages of 12.5, 50, and 100 mg/kg/d, respectively. Compared with the cisplatin group, mice treated with CP2-S exhibited a significant increase in spleen index (increased 22.7-42.4%) and thymus index (increased 47.7-36.8%). Additionally, serum levels of IgM and IgG in tumor-bearing mice increased by approximately 6.11 similar to 10.75-folds and 1.31 similar to 1.38-folds, respectively. These findings prove that CP2-S significantly inhibited the growth of Lewis lung carcinoma through immune-enhancing activity in mice.

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