Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2

文献类型： 外文期刊

第一作者： Chen, Chuangjiang

作者： Chen, Chuangjiang;Wang, Chenlong;Jiang, Hui;Wang, Mengya;Zhao, Chang;Huang, Wanyue;Wang, Xichun;Rahman, Sajid Ur;Chen, Changjiang;Ding, Hongyan

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关键词： zearalenone; rutin; Nrf2; endoplasmic reticulum stress; apoptosi

期刊名称：TOXINS （ 影响因子：4.0； 五年影响因子：4.5 ）

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年卷期： 2025 年 17 卷 1 期

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收录情况： SCI

摘要： Zearalenone (ZEA) is a mycotoxin commonly found in moldy cereals and has a range of toxic effects that have seriously affected animal husbandry. Rutin, a natural flavonoid with antioxidant activities, has been studied for its potential involvement in mitigating ZEA-induced apoptosis in porcine endometrial stromal cells (ESCs) and its potential molecular mechanism, particularly concerning the expression of Nrf2. This study investigates the molecular pathways by which rutin alleviates ZEA-induced ESC apoptosis, focusing on the role of Nrf2. Experimental data reveal that ZEA suppresses Nrf2 nuclear translocation and reduces mitochondrial membrane potential (MMP), leading to oxidative stress, endoplasmic reticulum stress (ERS), and mitochondrial pathway-driven apoptosis. Notably, rutin mitigates ZEA-induced apoptosis through Nrf2 activation. These findings highlight Nrf2 as a critical factor in rutin's protective effects against ZEA-induced apoptosis, offering valuable insights for the clinical prevention and treatment of ZEA toxicity.

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