Strongly-adhesive easily-detachable carboxymethyl cellulose aerogel for noncompressible hemorrhage control

文献类型： 外文期刊

第一作者： Pan, Siwen

作者： Pan, Siwen;Li, Yige;Chen, Lei;Wang, Li;Zhang, Qiang;Tong, Xinru;Li, Tao

作者机构：

关键词： Hemostatic aerogel; Covalent adhesion; Easy to remove; Antibacterial; Noncompressible hemorrhage

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：11.2； 五年影响因子：10.2 ）

ISSN： 0144-8617

年卷期： 2023 年 301 卷

页码：

收录情况： SCI

摘要： Hemostats that can strongly adhere to wound tissue and are easy to remove when stopping bleeding are favored for the control of noncompressible hemorrhage. Here, we prepared a citric acid (CA)-crosslinked and Nhydroxysuccinimide (NHS) ester-activated carboxymethyl cellulose (CMC-NHS) aerogel for noncompressible hemostasis. CA was used to crosslink CMC to form a strengthened structure. NHS ester was introduced to activate the adhesion of CMC-NHS aerogel to wound tissue and promoted blood coagulation through the formation of amide crosslinks between CMC and erythrocytes and free blood proteins. The plentiful carboxyl groups could also trigger the intrinsic coagulation pathway. Thus, the aerogel could quickly adhere to wound tissue to stop bleeding, and then could be easily removed when fully hydrated as CMC was dissolved at the adhesion interface. The aerogel also had good biocompatibility and antibacterial capability. Overall, CMC-NHS aerogel is a competitive hemostat for the control of noncompressible hemorrhage.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序