ADAMTS9-AS2 Promotes Angiogenesis of Brain Microvascular Endothelial Cells Through Regulating miR-185-5p/IGFBP-2 Axis in Ischemic Stroke

文献类型： 外文期刊

第一作者： Feng, Nianping

作者： Feng, Nianping;Wu, Yun;Jiang, Xiaohong;Wang, Zhi;Wang, Zhengfei;Zheng, Haihong;Qu, Fujun;Zhang, Zhuo

作者机构：

关键词： Ischemic stroke; ADAMTS9-AS2; miR-185-5p; Angiogenesis; IGFBP-2

期刊名称：MOLECULAR NEUROBIOLOGY （ 影响因子：5.682； 五年影响因子：5.576 ）

ISSN： 0893-7648

年卷期： 2022 年 59 卷 4 期

页码：

收录情况： SCI

摘要： Ischemic stroke is a common disease threatening human health. ADAMTS9-AS2 is a lncRNA that has been widely studied in tumors, but not in ischemic stroke. The purpose of this study was to investigate the role and potential molecular mechanism of ADAMTS9-AS2 in endothelial cell function after ischemic stroke in vivo and in vitro. The results showed that ADAMTS9-AS2 was decreased in the plasma of acute ischemic stroke (AIS) patients and in the brain tissue and plasma of MCAO mice, and the low expression of ADAMTS9-AS2 was associated with the increase in infarct size. Besides, compared with the control group, MCAO treatment slightly promoted angiogenesis, which was enhanced by the overexpression of ADAMTS9-AS2. Molecular mechanism results indicated that ADAMTS9-AS2 and miR-185-5p affected the pathological process of ischemic stroke through ceRNA mechanism, and IGFBP-2 was a downstream target gene of miR-185-5p. These findings demonstrated that ADAMTS9-AS2 promoted angiogenesis through regulating miR-185-5p/IGFBP-2 axis, suggesting that ADAMTS9-AS2 may be a potential marker for the diagnosis and treatment of neurological diseases.

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