The crosstalk between viral RNA- and DNA-sensing mechanisms

文献类型： 外文期刊

第一作者： Cai, Chunmei

作者： Cai, Chunmei;Xu, Guocai;Tang, Yan-Dong;Zheng, Chunfu;Tang, Yan-Dong;Cai, Chunmei;Xu, Guocai;Zheng, Chunfu

作者机构：

关键词： DNA sensing; RNA sensing; Crosstalk; Viral infection; Type I interferon

期刊名称：CELLULAR AND MOLECULAR LIFE SCIENCES （ 影响因子：9.261； 五年影响因子：9.074 ）

ISSN： 1420-682X

年卷期：

页码：

收录情况： SCI

摘要： Viral infections pose a severe threat to humans by causing many infectious, even fatal, diseases, such as the current pandemic disease (COVID-19) since 2019, and understanding how the host innate immune system recognizes viruses has become more important. Endosomal and cytosolic sensors can detect viral nucleic acids to induce type I interferon and proinflammatory cytokines, subsequently inducing interferon-stimulated genes for restricting viral infection. Although viral RNA and DNA sensing generally rely on diverse receptors and adaptors, the crosstalk between DNA and RNA sensing is gradually appreciated. This minireview highlights the overlap between the RNA- and DNA-sensing mechanisms in antiviral innate immunity, which significantly amplifies the antiviral innate responses to restrict viral infection and might be a potential novel target for preventing and treating viral diseases.

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