The Cellular Mechanism of Acupuncture for Ulcerative Colitis based on the Communication of Telocytes

文献类型： 外文期刊

第一作者： Bai, Xuebing

作者： Bai, Xuebing;Mei, Lu;Shi, Yonghong;Huang, Haixiang;Guo, Yanna;Liang, Chunhua;Yang, Min;Wu, Ruizhi;Zhang, Yingxin;Chen, Qiusheng;Shi, Yonghong

作者机构：

关键词： acupuncture; meridian; telocyte; TRPV4; ulcerative colitis

期刊名称：MICROSCOPY AND MICROANALYSIS （ 影响因子：2.8； 五年影响因子：3.3 ）

ISSN： 1431-9276

年卷期： 2023 年 29 卷 3 期

页码：

收录情况： SCI

摘要： Acupuncture can ameliorate or treat diseases according to the meridian theory in traditional Chinese medicine (TCM); however, its mechanism has not been scientifically clarified. On the other hand, telocytes (TCs) are morphologically in accordance with the meridian system, which needs further cytological investigations and acupuncture confirmation. The present study showed that acupuncture could activate TCs in several ways, alleviating rabbit ulcerative colitis. TCs could cytologically communicate the acupoints, the acupuncture sites in skin with their corresponding large intestine by TC homo-cellular junctions, exosomes around TCs, and TC-mediated nerves or blood vessels. TCs expressed transient receptor potential vanilloid type 4, the mechanosensitive channel protein that can transduce the mechanical stimulation of acupuncture into biochemical signals transferring along the extremely thin and long TCs. Collectively, a cellular mechanism diagram of acupuncture was concluded based on TC characteristics. Those results also confirmed the viewpoint that TCs were the key cells of meridian essence in TCM.

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