Identification of SNPs and expression patterns of ALB, AHSG and GC genes and their association with growth traits in Hu sheep

文献类型： 外文期刊

第一作者： Zhao, Liming

作者： Zhao, Liming;Wang, Weimin;Wang, Xiaojuan;Li, Xiaolong;Zhao, Yuan;Zhang, Yukun;Xu, Dan;Cheng, Jiangbo;Wang, Jianghui;Li, Wenxin;Lin, Changchun;Zhang, Xiaoxue;Zheng, Wenxin;Wu, Weiwei;Wang, Weimin;Zhang, Deyin

作者机构：

关键词： Hu sheep; ALB; AHSG; GC; Growth traits; Association; SNP; qRT-PCR

期刊名称：GENE （ 影响因子：3.5； 五年影响因子：3.3 ）

ISSN： 0378-1119

年卷期： 2023 年 853 卷

页码：

收录情况： SCI

摘要： Growth traits are economically important traits in sheep breeding. This study was conducted to evaluate the polymorphisms of ALB, AHSG and GC genes and their association with growth traits in Hu sheep. We measured and recorded the body weight (BW), body height (BH), body length (BL) and feed conversion ratio (FCR) of 1418 male Hu sheep raised in the same environment from 80 to 180 days of age. The total of four SNPs in the ALB, AHSG and GC genes were identified by direct sequencing technology. The results of association analysis showed that two loci (g.8699 A>T and g.13458 T>C) of ALB gene significantly affect average daily gain (ADG; P < 0.05). The genotypes of SNP g.2454 T>C in AHSG gene were significantly associated with ADG and FCR (P < 0.05). There were significant associations between GC g.19484 A>C and BW, BH and BL (P < 0.05). The results of qRTPCR showed that ALB, AHSG, and GC genes were extremely significantly higher in H_BW sheep compared with those in the L_BW sheep (P < 0.01). These results revealed that ALB-1 g.8699 A>T, ALB-2 g.13458 T>C, AHSG g.2454 T>C and GC g.19484 A>C loci are potential molecular markers for Hu sheep breeding.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序