Study on the pharmacodynamic substances and mechanism of hepatoprotection of Acanthus ilicifolius Linn.

文献类型： 外文期刊

第一作者： Zhang, Mengqi

作者： Zhang, Mengqi;Sun, Jinyue;Liu, Chao;Zhang, Dahu;Ren, Xia;Yue, Shijun;Li, Ningyang;Bai, Shujin;Wang, Changyun

作者机构：

关键词： Acanthus ilicifolius l.; Liver protection; Mechanism of action; Pharmacodynamic substances; Acteoside

期刊名称：PHYTOMEDICINE （ 影响因子：8.3； 五年影响因子：8.0 ）

ISSN： 0944-7113

年卷期： 2025 年 140 卷

页码：

收录情况： SCI

摘要： Background: The coastal wetland mangrove plant Acanthus ilicifolius l. (AI) is used as traditional medicine for liver protection and liver fibrosis treatment, but the pharmacodynamics of the hepatoprotective substance and the mechanisms of liver protection are not clear. Purpose: This work aimed to assess the liver-protective ability of AI and elucidate the pharmacodynamics of the hepatoprotective substance of AI responsible for its liver activity. Study Design and Methods: This study first appraised the hepatoprotective activity of the alcohol extract of AI. To identify the hepatoprotective substance in AI, network topology and the contribution index were comprehensively analyzed and screened. The screened medicinal substances, acteoside (ACT) and isoacteoside (IACT), were tested for hepatoprotective activity using mouse liver damage model and l-02 hepatocyte injury model, and metabolomics was employed to explore the mechanism of liver protection. Results: AI could restore the biochemical indicators of liver damage induced by CCl4 to normal conditions. The phenylethanoid glycoside compounds ACT and IACT, are the hepatoprotective substances of AI. ACT protects the liver tissue by regulating alpha-linolenic acid metabolism, glycerophospholipid metabolism, and amino acid-related pathway. Conclusion: This research provides basic information of the research and development of liver-protective effects of AI and ACT.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序