Self-assembly antimicrobial peptide for treatment of multidrug-resistant bacterial infection

文献类型： 外文期刊

第一作者： Ma, Xuanxuan

作者： Ma, Xuanxuan;Yang, Na;Mao, Ruoyu;Hao, Ya;Li, Yuanyuan;Guo, Ying;Teng, Da;Wang, Jianhua;Ma, Xuanxuan;Huang, Yinhua;Ma, Xuanxuan;Yang, Na;Mao, Ruoyu;Hao, Ya;Li, Yuanyuan;Guo, Ying;Teng, Da;Wang, Jianhua

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关键词： Antimicrobial peptide N6; Self-assembly; Nanoparticles and nanofibers; Stability; Bacterial-capture; Bovine mastitis

期刊名称：JOURNAL OF NANOBIOTECHNOLOGY （ 影响因子：12.6； 五年影响因子：12.3 ）

ISSN：

年卷期： 2024 年 22 卷 1 期

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收录情况： SCI

摘要： The wide-spreading of multidrug resistance poses a significant threat to human and animal health. Although antimicrobial peptides (AMPs) show great potential application, their instability has severely limited their clinical application. Here, self-assembled AMPs composed of multiple modules based on the principle of associating natural marine peptide N6 with ss-sheet-forming peptide were designed. It is noteworthy that one of the designed peptides, FFN could self-assemble into nanoparticles at 35.46 mu M and achieve a dynamic transformation from nanoparticles to nanofibers in the presence of bacteria, resulting in a significant increase in stability in trypsin and tissues by 1.72-57.5 times compared to that of N6. Additionally, FFN exhibits a broad spectrum of antibacterial activity against multidrug-resistant (MDR) gram-positive (G+) and gram-negative (G-) bacteria with Minimum inhibitory concentrations (MICs) as low as 2 mu M by membrane destruction and complemented by nanofiber capture. In vivo mouse mastitis infection model further confirmed the therapeutic potential and promising biosafety of the self-assembled peptide FFN, which can effectively alleviate mastitis caused by MDR Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), and eliminate pathogenic bacteria. In conclusion, the design of peptide-based nanomaterials presents a novel approach for the delivery and clinical translation of AMPs, promoting their application in medicine and animal husbandry.

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