Coordinating precursor supply for pharmaceutical polyketide production in Streptomyces

文献类型： 外文期刊

第一作者： Li, Shanshan

作者： Li, Shanshan;Xiang, Wensheng;Li, Zilong;Pang, Shen;Wang, Weishan;Wang, Weishan;Wang, Weishan

作者机构：

期刊名称：CURRENT OPINION IN BIOTECHNOLOGY （ 影响因子：9.74； 五年影响因子：9.807 ）

ISSN： 0958-1669

年卷期： 2021 年 69 卷

页码：

收录情况： SCI

摘要： The widely used polyketide pharmaceuticals in medicine and agriculture are mainly produced by Streptomyces species. These compounds, as secondary metabolites, are not involved in essential cellular processes and are usually produced during the stationary phase of fermentation. Consequently, their yields and productivities are often low and frequently limited by the availability of the precursors. The precursor pathways, therefore, are key entities for synthetic biology-driven design and optimization. We discuss recent advances in precursor engineering, in both Streptomyces and other bacteria, focusing on the diverse native and heterologous precursor pathways that could be rewired for polyketide titer improvement. We also highlight the coordination of other required factors to direct the precursors towards polyketide biosynthesis. The precursor-supply enhancement tools and strategies covered in this review will facilitate the design and construction of synthetic Streptomyces tell-factories' for efficient polyketide production.

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