Humulane-Type Macrocyclic Sesquiterpenoids From the Endophytic Fungus Penicillium sp. of Carica papaya

文献类型： 外文期刊

第一作者： Wang, Fu-Run

作者： Wang, Fu-Run;Yang, Li;Ma, Qing-Yun;Xie, Qing-Yi;Zhao, You-Xing;Wang, Fu-Run;Wu, You-Gen;Chen, Ping;Xiao, Na;Kong, Fan-Dong;Dai, Hao-Fu

作者机构：

关键词： endophytic fungus; Penicillium sp; humulane-type sesquiterpenoid; anti-diabetic activity; cAMP accumulation

期刊名称：FRONTIERS IN CHEMISTRY （ 影响因子：5.545； 五年影响因子：5.869 ）

ISSN： 2296-2646

年卷期： 2021 年 9 卷

页码：

收录情况： SCI

摘要： Three new humulane-type sesquiterpenoids, penirolide A (1), penirolide B (2), and 10-acetyl-phomanoxide (3), together with three known compounds aurasperone A (4), pughiinin A (5), and cyclo(l-Leu-l-Phe) (6) were isolated from the endophytic fungus Penicillium sp. derived from the leaves of Carica papaya L. Their structures including their absolute configurations were determined based on the analysis of NMR and HRESIMS spectra, NMR chemical shifts, and ECD calculations. Compounds 2, 3, 5, and 6 significantly inhibited glucagon-induced hepatic glucose production, with EC50 values of 33.3, 36.1, 18.8, and 32.1 mu M, respectively. Further study revealed that compounds 2, 3, 5, and 6 inhibited hepatic glucose production by suppression of glucagon-induced cAMP accumulation.

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