Multi-omics reveals host metabolism associated with the gut microbiota composition in mice with dietary epsilon-polylysine

文献类型： 外文期刊

第一作者： Zhang, Xuelei

作者： Zhang, Xuelei;Hou, Zhenping;Tian, Xu;Wu, Duanqin;Dai, Qiuzhong

作者机构：

期刊名称：FOOD & FUNCTION （ 影响因子：6.317； 五年影响因子：6.375 ）

ISSN： 2042-6496

年卷期： 2022 年 13 卷 7 期

页码：

收录情况： SCI

摘要： This study aimed to assess the influence of dietary supplementation of epsilon-polylysine on the gut microbiota and host nutrient metabolism, which is not systematically discussed by multi-omics analysis. A total of 40 mice were randomly divided into two groups exposed to either a basal diet (AIN-76A) or a basal diet with 150 ppm epsilon-polylysine. Fecal samples were collected for gut bacteria identification. Liver and plasma samples were collected for metabolomic and proteomic analyses. The results showed that epsilon-polylysine decreased the body weight of mice and affected the presence of certain types of intestinal microorganisms. The richness of the microbiota and number of phyla increased with age. epsilon-Polylysine affected the presence of genera and species, and either regulated or took part in the metabolism of energy, nitrogen, amino acids, lipids, carbohydrates, glycans, cofactors, and vitamins. The metabolite profiling showed that lipid and lipid-like molecules metabolites occupied the majority percent of plasma and liver metabolites. Additionally, epsilon-polylysine regulated the key role of metabolites and related metabolic enzymes in the metabolic pathways, especially phospholipid metabolism. In conclusion, dietary epsilon-polylysine improved the immunity of growing mice, and had a greater effect on the anabolism of nutrients in adult mice.

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