Orf Virus VIR Antagonizes p53-Mediated Antiviral Effects to Facilitate Viral Replication

文献类型： 外文期刊

第一作者： Yan, Ming-Hao

作者： Yan, Ming-Hao;Wang, Ling-Ling;Hao, Jun-Hong;Zhang, Xue-Gang;Shen, Chao-Chao;Zhang, Da-Jun;Zheng, Hai-Xue;Liu, Xiang-Tao;Zhang, Ke-Shan

作者机构：

关键词： Orf virus; VIR gene; antiviral effects; p53; immune escape

期刊名称：VIRAL IMMUNOLOGY （ 影响因子：2.257； 五年影响因子：1.882 ）

ISSN： 0882-8245

年卷期： 2020 年 33 卷 6 期

页码：

收录情况： SCI

摘要： As a zoonotic disease, ovine contagious pustular dermatitis (Orf) is a serious threat to sheep as well as humans. Orf virus (ORFV) interferon resistance protein (VIR) is the principal virulence protein that encodes a dsRNA-binding protein to inhibit host antiviral response. p53 is one of the key proteins of the host antiviral innate immunity. It not only enhances type I interferon secretion but also induces apoptosis in infected cells, and plays a crucial role in the immune response against various viral infections. However, it remains to be elucidated what role p53 plays in ORFV replication and whether ORFV's own protein VIR regulates p53 expression to promote self-replication. In this study, we showed that p53 has an antiviral effect on ORFV and can inhibit ORFV replication. In addition, ORFV nonstructural protein VIR interacts with p53 and degrades p53, which inhibits p53-mediated positive regulation of downstream antiviral genes. This study provides new insight into the immune evasion mediated by ORFV and identifies VIR as an antagonistic factor for ORFV to evade the antiviral response.

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