Combined toxic effects of fludioxonil and triadimefon on embryonic development of zebrafish (Danio rerio)

文献类型： 外文期刊

第一作者： Wang, Yanhua

作者： Wang, Yanhua;Wang, Dou;Weng, Hongbiao;Yang, Guiling;Guo, Dongmei;Yu, Ruixian;Wang, Xinquan;Wang, Qiang;Xu, Chao

作者机构：

关键词： Joint toxicity; Enzymatic activity; Gene expression; Aquatic toxicology

期刊名称：ENVIRONMENTAL POLLUTION （ 影响因子：8.071； 五年影响因子：8.35 ）

ISSN： 0269-7491

年卷期： 2020 年 260 卷

页码：

收录情况： SCI

摘要： Pesticides scarcely exist as individual compounds in the water ecosystem, but rather as mixtures of multiple chemicals at relatively low concentrations. In this study, we aimed to explore the mixture toxic effects of fludioxonil (FLU) and triadimefon (TRI) on zebrafish (Danio rerio) by employing different toxicological endpoints. Results revealed that the 96-h LC50 values of FLU to D. rerio at multiple developmental stages ranged from 0.055 (0.039-0.086) to 0.61 (0.33-0.83) mg L-1, which were less than those of TRI ranging from 3.08 (1.84-5.96) to 9.75 (5.99-14.78) mg L-1. Mixtures of FLU and TRI exerted synergistic effects on embryonic zebrafish. Activities of total superoxide dismutase (T-SOD) and catalase (CAT) were markedly altered in most of the individual and pesticide mixture treatments compared with the control. The expressions of 16 genes involved in oxidative stress, cellular apoptosis, immune system and endocrine system displayed that embryonic zebrafish were affected by the individual pesticides and their mixtures, and greater variations of four genes (ERa, Tnf, IL and bax) were found when exposed to pesticide mixtures compared with their individual compounds. Therefore, more studies on mixture toxicities among different pesticides should be taken as a priority when evaluating their ecological risk. (C) 2020 Elsevier Ltd. All rights reserved.

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